Messi started all those games, but the club has decided to rest the 37-year-old for what would have been his fourth game in just 12 days.
Miami are in CONCACAF action again on Thursday when they host Jamaican club Cavalier in the first-leg of their two legged tie with Messi expected to start in that game.
Inter's busy schedule continues into March with their first eight games of the season coming in the span of 26 days.
Listen to the latest songs, only on JioSaavn.com
Messi had trained on Friday with the rest of his team-mates including 38-year-old Uruguayan striker Luis Suarez, who has made the trip to Houston.
(This story has not been edited by staff and is auto-generated from a syndicated feed.)